ECP 2022 Abstract Book

Virchows Archiv (2022) 481 (Suppl 1):S1–S364 13 yellowish myocardium, myocardial hypertrophy; wine-coloured lungs with subpleural petechiae and mild oedema and congestion; ascitic fluid with a citrine appearance; liver with a micronodular appearance, firm consistency and yellowish coloration on cuts, with a diffusely hardened and yellowish parenchyma; yellow kid- neys with a finely granular surface and on cuts there is medullary congestion with a yellowish cortical zone. The histopathological study shows liver, heart and kidneys with diffuse extracellular dep- osition of amorphous, hyaline and eosinophilic material refracting to polarized light with Congo Red staining. Microscopic findings of deposits are consistent with amyloidosis. Conclusion: How there is no clinical and morphological evidence of active inflammatory or infectious disease, inferring this is pri- mary amyloidosis that justifies and explains the clinical picture and the Outcome otherwise, the clinical suspected septicemia was not set by the anatomo-pathological findings. E-PS-01-014 A clinical case of acute myocardial infarction with myomalacia in COVID-19 in a man with hypertension K. Kosov*, E. Guryanova, O. Vorobyeva, L. Romanova, N. Zhuravleva *Chuvash State University by I.N.Ulianov, Russia Background & objectives: The COVID-19 pandemic is a serious health threat. In addition to pulmonary complications, cardiovascular consequences are common. Purpose - to describe a case of infection with the SARS-CoV-2 virus with the development of acute myocardial infarction and myomalacia. Methods: According to the autopsy - the corpse of a man, 50 years old, a history of hypertension for 15 years. According to computed tomography - 75% lung damage. PCR test for covid-19 positive. The electrocardiogram showed signs of acute anterolateral myo- cardial infarction with myomalacia. Clinical and morphological analysis, virological method, staining of histological sections with hematoxylin-eosin were carried out. Results: Autopsy in the lungs revealed alternation of moderately airy alveoli with areas of dystelectasis. In the lumen of the alveoli, oedematous fluid, focally desquamated alveolocytes, macrophages, erythrocytes, and hyaline membranes along the contour of the alveoli were diffusely determined. In the heart - muscle fibres were frag- mented, focally wave-like curved. There were fields of non-nuclear necrotic cardiomyocytes with perifocal neutrophilic infiltration. Elec- tron microscopic examination in the foci of myomalacia revealed damage to organelles, contractures of myofibrils, myocytolysis and disintegration of muscle cells with the formation of fine granular detritus. Plasmatization of the vascular wall, erythrocyte stasis with sludge phenomenon and precapillary fibrosis were determined. Conclusion: In this case, against the background of covid pneumo- nia, an acute myocardial infarction of the anterolateral wall of the left ventricle was determined, which was not extensive. Significant changes were revealed in non-infarction zones: plasmatization of the vascular wall, erythrocyte stasis with sludge phenomenon and precapillary fibrosis. The stromal vessels were filled with blood to varying degrees, signs of endotheliitis were detected. Early onset of myomalacia was noted, obviously associated with the severity of the process and hemodynamic instability. E-PS-02 | E-Posters Breast Pathology E-PS-02-001 Primary mucoepidermoid carcinoma of the breast - case report N. Ilieva*, D. Tashkova, A. Georgiev, V. Ivanov *Complex oncologic centre-Plovdiv, Bulgaria Background & objectives: In comparison to its counterpart in the salivary gland, primary mucoepidermoid carcinoma (MEC) of breast is a very rare entity, accounting for 0.2-0.3% of all breast carcinomas. There are only 41 cases described up to date in the English literature. Methods: We present a case of a 60-years old female patient with palpable lump in the upper lateral quadrant of her left breast. Ultrasonographic examination showed solid, malignant appearing lesion, 2.6 centimetres in greatest dimension and an adjacent area of clustered microcalcifications with diameter 2 centimetres. Core biopsy was performed, which was interpreted as a poorly differenti- ated triple-negative ductal carcinoma. Results: The patient underwent quadrantectomy with axillary lymph node dissection. Grossly, well-circumscribed lesion, 23 millimetres in diameter, with solid and cystic areas was found. Microscopically the tumour was composed of different proportions of mucinous, epidermoid and intermediate cells, arranged in solid sheets and cystic spaces, filled with mucoid material. Tumour cells exhibited immunonegativity for oestrogen, progesterone and HER-2 protein, but appeared to be positive for CK7, CK5/6, p63 and EMA. Additionally, 30% of the cells were positive for Ki-67. Based on the specific morphologic and immunohistochemical characteristics the lesion was histologically classified as mucoepidermoid carcinoma of intermediate grade. Conclusion: In conclusion, primary breast MEC is extremely rare, causing diagnostic and therapeutic challenges in the everyday practice. Although being triple-negative, it has favourable prognosis, especially for the low-grade histologic variants, with low risk for metastasis or recurrence. Reporting MEC cases is essential for better understanding of its clinical and biological behaviour and for establishing standard treatment strategies by the multidisciplinary team. E-PS-02-002 Neuroendocrine tumour of the breast showing invasive micro- papillary features and multiple lymph node metastases T. Kawasaki*, T. Tashima, K. Taniyama, J. Ichikawa, M. Saitoh, A. Fujimoto, A. Asano, H. Imada, C. Muramatsu, H. Nagai *Department of Pathology, Saitama Medical University Interna- tional Medical Center, Japan Background & objectives: The WHO classifies neuroendocrine neoplasms (NENs) as a special tumour entity, representing <1% of invasive breast carcinomas (IBCs), and recognises two subtypes: neuroendocrine tumour (NET) and neuroendocrine carcinoma. Herein, we present the first case with an invasive micropapillary mammary NET. Methods: A 65-year-old woman had become aware of a tumour in her right breast 11 months prior to presentation at our hospi- tal. Ultrasonography revealed a huge, cystic right breast tumour with enlarged regional nodes. No other lesions were identified by either systemic CT or bone scintigraphy. The patient underwent fine-needle aspiration of the mammary lesion, and the cytological diagnosis was carcinoma. Results: A well-demarcated, multinodular, red-brown tumour, which measured 15x15x15 cm, was found in the mastectomy specimen. Histopathologically, this solid and cystic lesion consisted of medullary growth of carcinoma cells accompanied by a highly developed vascular stroma. Carcinoma cell nests displayed a retraction artifact and antipolarity. Carcinoma cells were polygonal and possessed fine-granular cytoplasm S190