ECP 2022 Abstract Book

Virchows Archiv (2022) 481 (Suppl 1):S1–S364 13 confirmed the female sex of the relic, whereas the estimated age at death was earlier than that proposed by historians. Nei- ther vitamin nor nutrient deficiencies were found. The syphilis hypothesized by textual sources was excluded. A small rounded osteoma was detected by CT scan on the endocranial surface of the frontal bone. Interestingly, postmortem alterations of the relic were clearly visible at the top of the calvarium, demon- strating the worship of the relic since the death of the Blessed Maria Longo. Conclusion: The paleopathological and paleoradiological study of the relic of the Blessed Maria Longo revealed a woman whose death occurred at a younger age than that reported by textual sources. Maria Longo neither suffered of syphilis nor experienced dietary deficiencies. Her relic showed signs of worshiping dating from the early years after the death. E-PS-12-002 The Neapolitan Hospital for Incurables and the life and work of Domenico Cotugno M. Marino*, E. Manzillo *IRCCS Regina Elena Natl Cancer Inst. Rome, Italy Background & objectives: The purpose of this contribute is to describe the activities of Hospital for Incurables in Naples and to mention Domenico Cotugno’s life. He was an Italian scientist famous in all Europe for his research activities and views of modern medicine. Methods: According to our literature search, Maria Longo, the wife of Juan Lonc (Longo), Minister of the King Ferdinand the Catholic of Catalonia, founded in 1522 the Hospital of Incurables (people who nobody wanted to cure), and during the following years and centuries monastic orders were engaged in this Hospital, which was also considered the “Saint’s Hospital” (among them Luigi Gonzaga). Results: People affected by severe invalidating diseases were accepted in the Hospital: paralysis, epilepsy, icterus, syphilis, burns were among the diseases cured in the Hospital. The centre was so famous in Europe that many Gran Tour Tourists visited the Hospital, which was also a university site, during their trip to Naples. Domenico Cotugno, born in Ruvo pugliese in 1736 and graduated in Medicine at the Salerno medical school, became an assistant at the Hospital for incurables and, in 1761, professor of Surgery. He was professor of Anatomy and Director for 30 years of the Hospital, favouring a centre devoted to modify, with modern rules, the perspectives of the diseases. Conclusion: Domenico Cotugno was convinced that medicine has a strong social commitment: to cure and to save as many per- sons as possible, simple persons as well as nobles. Cotugno’s sci- entific activities on acqueducts of the human inner ear, on "De sedibus variolarum syntagma" were famous in Italy and Europe through the 18th century. For his promotion of vaccines, in Naples in 1807 Cotugno was named president of a committee promoting the vaccine against Smallpox. He was an outstanding example of physician-humanist. E-PS-12-003 From war to earthquake. 100 years of Institute of Pathology University of Zagreb School of Medicine S. Seiwerth*, D. Galešić Ljubanović, M. Kolić, S. Sikirić *UZSM, Croatia Background & objectives: WW 1 with all its horror led also to destruction of 3 out of 4 empires. In this, 1917. after 100 years of struggle with the Austrian Monarchy, founding of Faculty of Medicine was finally granted to Zagreb University. Methods: The search for faculty was not easy in these war and post-war times. So it was for Pathology chair. After several attempts (including Vaclav Neuman from Brno) Sergei Saltykow, also a prominent pathologist with great experience was elected. It was in 1922 the Institute of Pathology became operational both in teaching and diagnostics. Results: Its history was marked by struggle in order to finish the building, organize the teaching activity including a modern micros- copy room for the students, spacious autopsy room and a top mac- roscopy museum. The Institute soon became a turning point not only for teaching but also for histopathology diagnostics, covering large areas of the newly formed kingdom of Yugoslavia. Saltykow’s expertise together with great enthusiasm resulted also in a series of Pathology textbooks which remained the golden standard for decades to come. His followers expanded and modernized the insti- tute launching new laboratories (EM, histochemistry, immunohis- tochemistry, molecular pathology) and new teaching techniques. The tradition of textbooks also remained. Conclusion: In a moment where the vision of introducing new quality in diagnostic, teaching and research work appeared to become reality, the earthquake of March 22. 2020, seriously dis- rupted our plans. The teaching part of the institution can’t be used at all and we resumed our work under broken walls, which mean- while have been provisionally repaired. But we hope that the recon- struction will bring us the opportunity to realize our dreams, and maybe make them even better. E-PS-12-004 Influence of the French geodesic mission in the first micro- scopic findings in Ecuador S. Egüez, S. Hincapié*, M.E. Cruz, A. Orellana, G. Zuñiga *Instituto Oncológico Nacional Dr. Juan Tanca Marengo, Ecuador Background & objectives: The arrival of scientists from the French Geodesic Mission in Ecuador meant a time of academic boom that represented the first microbiological vision. European scientists gave us their most modern microscope built by John Cuff. Methods: We performed a review of textbooks and database Scielo addressing the origins of pathology in Ecuador, starting with the first microscope. Results: In Quito (1736), the French scientists delegates were welcomed by the Jesuits. After building a good relationship with Ecuadorian scientists, they gave them their modern microscope. Juan Bautista Aguirre, Ecuadorian priest and scientist, described the first findings in the "Tratado de Física"(1759), in which he described that diseases and plagues are caused by malignant worms and transmission. Years later, Marco Von Plenciz; a Slovenian doctor, published "Opera medico-physica"(1762), stating that microorganisms are the cause of diseases. Due to the European intellectual construction and the Jesuits at the University of San Gregorio, first Ecuadorian physician, Eugenio Espejo began his multiple microbiological thoughts in Ecuador (1785). Conclusion: The geodesic mission that granted the first microscope in Ecuador, contributed to the knowledge of epidemics that caused high morbidity and mortality. This new development led to academic reconstruction in Ecuadorian society. E-PS-12-005 N.I. Pirogov and the doctrine of vessels and vascular pathology M. Mnikhovich, A. Romanov, T. Bezuglova, T. Sotnikova* *Moscow City Clinical Hospital No.23, Russia S292