ECP 2022 Abstract Book

Virchows Archiv (2022) 481 (Suppl 1):S1–S364 13 Y. Gómez Navarro*, M. Garcia Martos, C.M. Vieru, A. Panizo Santos *Hospital General Universitario, Spain Background & objectives: The term arthrogryposis is used to denote contractures involving at least two joints in different body regions. The most prevalent type is amyoplasia, which may have a higher prevalence in monozygotic twins; however, it usually only impacts one of them. Methods: We present a case of a primiparous woman without any anteced- ents, with a bicorial and biamniotic gestation in her 31st week. In a routine ultrasound study, discordance between both foetuses, raised nuchal fold and claw hand was observed in one of them. It concluded with a feticide and request for an autopsy after the birth of the second twin. Results: A male foetus with a multiarticular flexion position, with skin shortening in the neck (pseudoterigium) was received in our service. Accompanying the joint contractures, marked general- ized muscle atrophy (amyoplasia) was identified due to the lack of intrauterine mobility because of these contractures. In addition, he had clawed hands and macroglossia. The complementary studies of chromosomopathies and genetics for neuromuscular diseases did not identify any alterations that justified the origin of the foetal pathology detected. The prenatal ultrasound and autopsy findings in our case were characteristic of arthrogryposis. Conclusion: The incidence of arthrogryposis is approximately 1/3000 live births; however, the prenatal incidence indicates a high intrauterine mortality. More than 400 specific disorders presenting with arthrogryposis have been identified. Its aetiology is highly heterogeneous with a background of genetic disorders with variable prognosis and inheritance. The most prevalent form is amyoplasia. Current ultrasound identifies approximately 25% of cases before 24 weeks in general obstetrics care population. E-PS-20-007 The attitude and general knowledge concerning perinatal autopsy in midwivery bachelor students and hospital midwives in internet querend J. Gulczynski*, M. Michalski, S. Goertz, E. Izycka-Swieszewska *Dept. of Pathology and Neuropathology, Medical University of Gdansk, Poland Background & objectives: We tried to assess knowledge about peri- natal autopsy among bachelor students and midwives. Unanonimous students’ request to see one during seminars attracted our attention. We decided to assess attitude and knowledge of this procedure through online querend in other universities. Methods: Getting positive feedback after presenting recorded autopsies to the students we decided to assess the general knowledge of this procedure, attitude, experience, benefits coming from autopsy among wider spectrum of students and university hospital midwives. Online querend was divided into standard sections describing respondents, medical background, experience, knowledge, the attitude, opinions about the possible benefits coming from such autopsies. Results: More than 300 students answered the querend, and about 190 midwives so far. The final results will be presented during the Congress as we still gather the data. The results are quite aston- ishing because overwhelming majority fully understands the need of the perinatal autopsy, with will to attend it if possible (0 to 1 seen so far). The experience is based mainly on written or internet sources. Majority of respondents sees the benefits of postmortem examination for future family counselling (inherited disorders), future perinatal care, correlations with prenatal ultrasound diag- nostics. Almost all respondents consider information from autopsy vital for future professional work. Conclusion: Perinatal autopsy has not yet suffered from dramatic decline as others. After this querend we learn that knowledge from this procedure (so far limited to physicians) is noticed and acknowl- edged by other medical professionals. Due to obvious obstacles personal attendance is mostly impossible, but in era of digitalisa- tion, remote presence, post factum analysis is available for every medical interested in extra practical knowledge. Discussing results might be an enormous source of information for every part, espe- cially in rare cases. E-PS-20-008 Placental incidental finding in a context of a giant congenital melanocytic nevus – a case report A. Leuca*, V. Segers, C. Dangoisse, A. Raat *CHU Brugmann, Brussels, Belgium Background & objectives: Melanocyte aggregates within the placenta raise a differential diagnosis between benign nevus and a metastasis of a maternal or foetal melanoma. The association with congenital mel- anocytic nevi of the newborn is a rare, but already described condition. Methods: After an uncomplicated pregnancy, a healthy woman gave birth at term. The female infant showed a giant congenital melanocytic nevus in the left lower extremity, with multiple satel- lite lesions and a thoracic infantile haemangioma. The placenta was sent for pathological examination. Multiple skin resections of the lesions were also performed. Results: The macroscopic aspect of the placenta was normal. The microscopic examination showed well-delineated incidental cell aggregates within the chorionic villi. These cells were focally pigmented and did not exhibit any cytological atypia. They were absent in the intervillous space. No mitoses could be found. The cells were positive for MelanA red and S100 immunohistochemical stains. HMB45 antibody expression was positive. The microscopic and immunohistochemical examinations of the infant’s main mel- anocytic lesion and the satellite lesions showed features consistent with congenital nevi, without any malignant transformation. Close clinical follow-up of the infant is still ongoing. Conclusion: Incidental ectopic tissue in the placenta (such as adrenocortical, liver parenchyma) is rare. On the other hand, the differential diagnosis comprises malignant entities, such as metastatic tumour from maternal or foetal origin. The current case report illustrates a rare placental finding (melanocytic nevi cells) in a context of a giant congenital melanocytic nevus of the infant with no signs of malignant transformation at the moment of reporting. E-PS-20-009 Spinal neurenteric cyst: a case report I. Msakni*, R. Aouadi, N. Mansouri, F. Gargouri, M. Ben Thayer, K. Tlili, B. Laabidi *Department of Pathology, Military Hospital of Tunis, Tunisia Background & objectives: The neurenteric cyst is a rare con- genital deformity, It has a predilection for the lower cervical and upper dorsal region. We present a case of intradural intramedullary spinal neurenteric cyst and discuss its clinicopathological features. Methods: We report a case of spinal neuroenteric cyst i a 11 year- old child. Results: An 11-year old child presented with neck pain and gait problems evolving for six months. Magnetic resonance imaging (MRI) was performed and showed intradural and intramedullary cystic formation at the level of C5-C6, isointense to cerebrospinal S324