ECP 2023 Abstracts

S300 Virchows Archiv (2023) 483 (Suppl 1):S1–S391 13 questionnaire developed by me. Born in Simpheropol in family of teacher of Russian language and literature. Graduated from Medical Faculty of 2nd Moscow University. Methods: Work in various positions at 2nd Moscow Medical Institute; defense of doctoral dissertation on topic "The role of nonspecific aller- gies in the occurrence and localization of respiratory tuberculosis", awarded by People’s Commissariat of Health; service in Red Army: chief pathologist on various fronts; after severe brain confusion and fracture of right shoulder, he was demobilized (1944). Results: Head of Laboratory of Pathological Anatomy of Institute of Normal and Pathological Morphology in Moscow, etc. after refusing the offer, in cooperation with Moscow State Security authorities, He was relieved of his post as hotbed of "Virchowianism"; arrest, charges of participating in terrorist Jewish organization of "killer doctors" investigation terminated, released from custody with full rehabilita- tion (1953). Head of Pathomorphology Laboratory at the A.N.Bakulev Institute of Cardiovascular Surgery; he left the institute at age of 80 and was engaged in viewing histopreparations at home until almost 95 years old; described allergic myocarditis and obtained experimental model of myocarditis when various antigens were injected into body. Conclusion: Proposed etiopathogenetic classification of myocarditis; formulated the concept of "resuscitation pathology" and singled out "resuscitation traumatology" from it; pointed to effectiveness of trans- vasal heart biopsy for diagnosis of myocarditis. Research interests: Infectious, cardiovascular pathology, etc. Author of more than 200 scientific papers. Motto: "Catch a moment of luck." "The pathologist holds in his hands not only corpses, but also fate of living person". Hobbies: Photography, theater, music. Died in Moscow at age of 98 and was buried at Golovinsky cemetery. E-PS-13-009 Professor Aron Iudovich Zelensky - Russian pathologist, scientist and educator (11.06.1912-19.03.1983) A. Zubritsky* *Russia Background & objectives: This work has the aim to collect and sys- tematize the biographical data on A.I.Zelensky in accordance with the questionnaire I have developed. Born in Kansk, Krasnoyarsk Krai in family of an employee. Graduated from the Khabarovsk Medical Institute (1936). Methods: As a 4th year student, he was trusted to conduct practical classes at Pathology Department; PhD thesis defense on topic "Renal vein thrombosis in amyloid-lipoid nephrosis" (1945); doctoral - on topic "Acute venous stasis of kidneys and its role in pathogenesis of renal syndrome in haemorrhagic nephrosis-nephritis" (1969). Assistant, Associate Professor, Head, Pathology Department, etc. Chief Patholo- gist of Khabarovsk region. Results: contributed to organization of biopsy and sectional work in Far East; the founder of original concept of renal syndrome of haem- orrhagic nephroso-nephritis, and modelling of clinical and morpho- logical syndromes of haemorrhagic fever with renal syndrome in the experiment allowed to justify a more effective pathogenetic therapy of this severe disease; under his leadership, 3 doctoral and 20 candi- date dissertations were completed and defended; awarded medals "For the Victory over Germany", "For Labor Valor", "For Valiant Labor in the Great Patriotic War of 1941-1945", etc. Scientific interests: The problem of renal pathology, issues of teaching, training and improve- ment of the pathoanatomical service in city and region. Author of 57 scientific papers. Conclusion: Member of the CPSU, Board of the All-Union Scientific Society of Pathologists, Chairman of the Regional Society of Patholo- gists. Distinctive feature: General erudition, great pedagogical skills and deep professional knowledge, an amazing ability to combine the rigor and exactingness of the head with the care and attention of an older comrade and friend. He died at the age of 70 from acute recur- rent myocardial infarction. His name is included in the University’s Book of Honor. E-PS-14 | E-Posters Infectious Diseases Pathology E-PS-14-002 Placental malaria in a patient with sickle trait haemoglobin: an infrequent finding I. Fernández*, S. Fernández, A. Tarín, J. Rosselló, L. Aguirrezabal, C. Valentí, G. Cancho, A. Nogueira *Hospital Universitario de Basurto, Bilbao, Spain Background & objectives: Malaria is the most prevalent vector-borne disease in the world, but it was eradicated in Spain. Meanwhile, sickle cell trait protects carriers against severe malaria. We report a case of placental malaria in a patient with sickle trait haemoglobin. Methods: We present a case of a 27-year-old woman from Guinea on her 38 week of pregnancy, who is admitted to the hospital with pre- mature rupture of membranes. Although she referred normal prenatal care, laboratory data revealed anaemia, thrombocytopenia and leuko- penia. After a caesarean delivery, a healthy female child was born, and the placenta was submitted for histopathological and microbiological examination. Results: Histopathological study of the placenta showed presence of hemozoin; a dark-brown pigment, product of haemoglobin digestion, that accumulates inside maternal intervillous monocytes and infected red blood cells. As a consequence, there was perivillous fibrin deposi- tion and also syncytial knot formation. Furthermore, occasional struc- tures suggestive of parasites could be observed inside some red blood cells, and hemozoin pigment deposit in fibrin and stroma was con- cordant with chronic infection. Finally, occasional erythrocytes with anomalous morphology were found within intervillous space. This is likely to be due to a sickle trait haemoglobin, which was revealed later in blood analyses performed on the mother. Conclusion: Malaria in pregnancy is diagnosed when Plasmodium par- asites are found either in maternal peripheral blood or in the placenta. In our country, this circumstance is almost exclusive to immigrant preg- nant women. Therefore, in these cases it is important to bear in mind the possibility of this parasitic infection, since the histopathological changes in the placenta may provide a definitive diagnosis. Addition- ally, even though sickle cell trait confers some resistance to malaria, it does not completely protect against the infection. E-PS-14-003 Leukocytoclastic vasculitis after exposure to COVID-19 vaccine: report case F. Figueiredo*, S. Maria Macêdo, H. Neves Feitosa Filho, C.E. Maia Rodrigues, D. Coelho de Sá, D. Nunes Oliveira, J. Carneiro Melo, A.V. Pinto de Lima *Universidade de Fortaleza, Brazil Background & objectives: Leukocytoclastic vasculitis is an inflamma- tion that affects dermal capillaries and venules. This condition may be idiopathic or related to infections, malignancies, autoimmune disorders, or medications. This work aims to describe a case of leukocytoclastic vasculitis possibly consequent to SARS-CoV-2 vaccination. Methods: Case presentation based on summarization of patients clinical history, image findings, laboratorial exam, cytology and skin biopsy. Results: A 51-year-old patient received Pfizer SARSCoV immuniza- tion. He also referred the appearance of erythematous lesions, which extended to the lower limbs in less than 1 month after the vaccine and a month and a half later he developed bilateral ankle pain and swelling.