ISMRC 2023 Final Programme

13 Tuesday, 2 May 2023 – Scientific Programme OPENING REMARKS 09:00 – 09:30 a.m. Klaus Pantel, Germany Catherine Alix-Panabières, France Welcome address of the dean of the University Medical Centre Hamburg Blanche Schwappach-Pignataro, Germany SESSION 1 Cancer Biology Chairs: Catherine Alix-Panabières, France Christoph Wagener, Germany 09:30 – 10:00 a.m. Mechanisms of metastatic awakening Robert Weinberg, USA 10:00 – 10:30 a.m. Circulating tumor cell clusters Nicola Aceto, Switzerland 10:30 – 11:00 a.m. Tumor-derived extracellular vesicle DNA: novel configuration and immune regulation in cancer David Lyden, USA 11:00 – 11:15 a.m. Understanding the biomechanics of co- lon metastasis-competent CTCs using microchips mimicking microcapillaries of the bloodstream Keerthi Kurma, France 11:15 – 11:30 a.m. Deciphering the methylation signature of circulating extracellular vesicle DNA and cell-free DNA for CNS tumor clas- sification Franz Ricklefs, Germany 11:30 – 11:45 a.m. Coffee Break SESSION 2 Cancer Immunology Chairs: Klaus Pantel, Germany Samuel Huber, Germany 11:45 a.m. – 12:30 p.m. Insights from a thirty-year journey of PD-1: function, regulation and thera- peutic modulation Tasuko Honjo, Nobel Laureate 2018, Japan 12:30 – 01:00 p.m. Gut microbiota fingerprint predicting resistance to cancer immunotherapy Laurence Zitvogel, France 01:00 – 01:15 p.m. Treatment response monitoring using cell-free DNA fragmentation profiling Remond Fijneman, The Netherlands 01:15 – 01:30 p.m. Single cell transcriptome atlas reveals a high degree of hetereogeneity in NSCLC circulating tumor cells Melanie Janning, Germany 01:30 – 02:45 p.m. Lunch Break