161 / 366
lymphadenopathy (80.2 %). With respect to the histological sub-types,
nearly every case was classical HL, 34.3 % of the cases were identified as
having the mixed cellular type, 60.4 % had the nodular sclerosing type,
3.7 % had the lymphocyte rich type 1.4 % had th lymphocyte depleted
type. Bone marrow involvement was 10.2 %.
Conclusion:
Our epidemiological data are generally compatible with data
from both underdeveloped and developing countries. The results of im-
munohistochemical staining that we have obtained in this study are in line
with the literature data.
PS-08-060
Primary cutaneous acral CD8+ Tcell lymphoma: A new entity and a
rare case report
G. Akarca
*
, O. Erdem, N. Akyurek
*
Gazi University, Dept. of Medical Pathology, Ankara, Turkey
Objective:
Primary cutaneous acral CD8+ T cell lymphoma is a rare
tumour which has been described as a new indolent provisional entity,
originally described as originating in the ear. There has been described in
nose in a few cases. We present a case which has an indolent course in
nose.
Method:
Microscopy and immunohistochemical stains were applied.
Results:
A 56 years old man, presented with a wound on his nose since
2014. He has had some different diagnosis until this time, such as lupus
vulgaris, squamous cell carcinoma and T cell lymphoid hyperplasia. His
wound has not healed and a partial rhinectomy has applied. Microscopy
revealed a dense, diffuse lymphoid infiltration in dermis that consisted of
CD3+, CD8+, CD7+, TIA-1 + and granzyme + small/medium sized
lymphocytes. Atypical lymphoid infiltration also showed invasion in
the vessel wall and cartilage. There was focal necrosis in some areas.
Primary cutaneous acral CD8+ T cell lymphoma was diagnosed accord-
ing to histopathologic and immunohistochemical findings.
Conclusion:
Primary cutaneous acral CD8+ T cell lymphoma is a rare
tumour and is new entity. Primary cutaneous acral CD8+ T cell lympho-
ma is a rare tumour and a new entity. The lesions are nearly always
localized to a single site and therefore can be managed conservatively.
It
’
s important to know and remember this diagnosis because of the treat-
ment is unique.
PS-08-061
Investigation the presence of Epstein-Bar virus in diffuse large B-cell
lymphoma
A. Bugra
*
, F. R. Yildiz, S. Ozekinci, G. Ayaz, Z. B. Erdem, C. Cakir
*
Okmeydani Research Hospital, Pathology, Istanbul, Turkey
Objective:
Epstein-Bar Virus (EBV) positive diffuse large B cell lym-
phoma (DBLCL) is a new category in 2016 World Health Classification
of lymphoid neoplasms and it has been increasingly recognized in youn-
ger patients and better survival
Method:
61 patients with DLBCL has been included in this study. We
grouped with patients according to their ages as under 50 and above 50. We
used EBV coded RNA (EBER) chromogenic in situ hybridization method to
determine EBV in these cases. We also studied bcl-2, bcl-6 and c-myc immu-
nohistochemistry to these cases. EBER expression was specified as positive/
negative. Bcl-2, bcl-6 and c-myc expressions were grouped as their
percentages.
Results:
Sixteen of patients were under 50 years old and 45 of them were
above. EBER expression were seen in 4 patients and 3 of them under 50 years
old.
Conclusion:
EBV positive DLBCL can be seen in the young age group.
We suggest that EBER should be assessed in all ages in DLBCL. There
will be an opportunity to study and and develop targeted therapy in the
management of patients with EBV positive DLBCL.
PS-09-001
Neuroendocrine carcinomas of head and neck: Review of cases in La
Paz Hospital since 1965
D. C. Fuel Gómez
*
, Y. Brygadyr, D. Roldán Cortés, E. López Ruiz, J. J.
Pozo Kreilinger
*
La Paz Hospital, Dept. of Pathology, Madrid, Spain
Objective:
To review the neuroendocrine carcinomas (NEC) of head and
neck.
Method:
We searched and reviewed the NEC of head and neck area
diagnosed in La Paz Hospital since 1965.
Results:
We found 7 cases of NEC. Four in the salivary gland (3 in the
parotid and 1 in the submandibular gland), 2 in the larynx and 1 in the
oropharynx. Five were small cell NEC (SCNEC) and 2 large cell NEC
(LCNEC). The salivary gland carcinomas did not have metastasis but 1
patient died of the disease. Both laryngeal carcinomas had hepatic and
bone metastasis and died. The most recent patient is a 62-year-old woman
who presented with a mass in the right tonsil and uvula. She presented
with metastasis to the regional lymph nodes. She is being treated with
chemotherapy.
Conclusion:
NEC in head and neck localisation are extremely rare. In
our series, the most common site of presentation was the salivary
gland followed by the larynx. They were all poorly differentiated
tumours. All of them were tested to exclude metastasis from other
sites. The salivary gland NEC presented without metastasis and seem
to have a better prognosis.
PS-09-002
Case report: Hyalinising clear cell carcinoma
K. Kóczián
*
, N. Jani
*
National Institute of Oncology, Center of Tumour Pathology, Budapest,
Hungary
Objective:
Hyalinizing clear cell carcinoma (HCCC) is a rare,
low grade salivary gland carcinoma with excellent prognosis.
It must be distinguished from carcinomas with myoepithelial
d i f f e r e n t i a t i on , s qu amou s c e l l c a r c i noma ( SCC ) a nd
mucoepidermoid carcinoma (MEC). We report a case of a 59-
year-old male with HCCC of minor salivary gland. The pre-
excision biopsy sample from the tumour located at the root of
the tounge and the lateral wall of the pharynx was diagnosed as
basaloid SCC. Examining the tumour after complete resection
lead to the diagnosis of HCCC.
Method:
The tissue samples from the tumour were embedded in
paraffin; the slides were examined by light microscopy. P63,
S100, panCK, CK7, CK5, CK14, SMA, CD10, WT1, calponin,
p16 immunohistochemistry was performed. Fluorescence in situ
hybridization (FISH) was used to detect EWSR1 gene transloca-
tion. Periodic acid-Schiff (PAS) stain was also carried out.
Results:
The tumour cells were positive for p63, panCK, CK7, CK5 and
CK14. S100, SMA, CD10, WT1, calponin, p16 were negative. EWSR1
translocation was confirmed using FISH.
Conclusion:
We present a rare salivary gland carcinoma. Our case
showed similar morphologic features and immunohistochemical
profile to myoepithelial carcinoma. Detection of EWSR1 gene re-
arrangement helped to separate HCCC from its histological
mimics.
Monday, 4 September 2017, 09:30
–
10:30, Hall 3
PS-09 Head and Neck Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S147