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even focal presence of micropapillary pattern in an otherwise convention-
al urothelial carcinoma, is associated with advanced tumour stage and
poor prognosis.
E-PS-18-026
A benign tumour of the epididymis; Leiomyoma; Case report
S. Y. Celik*, Ö. Ilhan Çelik, Y. Dere
*Mugla Sitki Kocman University, Pathology, Turkey
Objective:
Epididymal tumours are very rare with the rate of 5 % of
intrascrotal tumours and 75 % of them are benign. The most frequent
benign tumours are adenomatoid tumours and leiomyomas.
Method:
Case Report: Our patient is a 41-year-old man. He was admitted
to urology clinic with a 1-year history of a slow-growing, painless mass in
his left scrotum. Ultrasonographic examination revealed a well-
circumscribed, solid, hypoechoic mass with a diameter of 1,5 cm in his
left epididymis. The mass at the tail of the epididymis was excised with its
well-circumscribed borders.
Results:
The histopathological evaluation; revealed a well-circumscribed
neoplastic proliferation of spindle cells with deeply eosinophilic, fibrillar
cytoplasm arranged in intersecting fascicles. Nuclear atypia, mitosis or
necrosis were not present. The neoplastic cells showed strong cytoplas-
mic staining for desmin, Smooth-muscle-actin(SMA) and Caldesmon. As
Ki-67 proliferation index was 1 %, the lesion was diagnosed as
Epididymal Leiomyoma(EL).
Conclusion:
EL is a benign tumour that can be cured through simple,
organ-preserving surgical excision. It is the second most common neo-
plasm of the epididymis, following adenomatoid tumour and represents
6 % of primary epididymal tumours. Although it is a rare lesion, EL
should be considered in differential-diagnosis of scrotal masses in order
to provide testicular preservation.
E-PS-18-027
Concordant occurrence of RCC and angiomyolipoma in the same
kidney
M. Milanka*
*University Hospital Osijek, Dept. of Pathology, Croatia
Objective:
Angiomyolipoma is a rare tumour often associated with tu-
berous sclerosis. Although its clinical course is usually benign, it may be
associated with various adverse outcomes.
Method:
A 52-year-old female patient underwent nephrectomy due to
kidney tumour. Two histologically different tumours were found directly
next to each other. RCC was 3.5 cm in diameter (pT1aNXMX, G3) and
angiomyolipoma diameter was 7 cm.
Results:
Both tumours were c-Kit and CK20 negative, and Vimentin
positive. Angiomyolipoma showed immunohistochemical positivity to
the MSA, SMA, HMB45, Melan A and CK AE1 / AE3, while it was
negative for EMA, RCC and CK7. Renal cell carcinoma showed immu-
nohistochemical positivity for EMA, RCC, CKAE1 / AE3 and CD10 and
focal positivity for CK7, while being negative for MSA, SMA, S-100,
HMB45 and Melan A.
Conclusion:
The paper presented a rare example of simultaneous appear-
ance of two histologically and immunohistochemically different tumours
in the same kidney, which were observed and documented with extensive
immunohistochemistry.
E-PS-18-028
Nephrogenic adenoma of the prostatic urethra: A case report
S. Y. Celik*, Ö. Ilhan Çelik, Y. Dere, L. Tekin
*Mugla Sitki Kocman University, Pathology, Turkey
Objective:
Nephrogenic adenoma(NA) is a rare proliferative lesion of the
urothelium. It is described in the urinary bladder. Nonspesific symptoms
such as hematuria, dysuria and bladder-irritability are the most frequent
complaints of the patients.
Method:
Case Report: Our patient is a 64-year-old man. He was admitted
to urology clinic with the complaints of dysuria, pollakuria and frequency
continuous for 2 weeks. He had a history of transurethral-resection(TUR)
for prostatic nodular hyperplasia. Cystoscopy was performed and small
suspicious papillary-lesions in the prostatic urethra were noticed and TUR
was applied.
Results:
In the histopathological evaluation; tubular structures lined by
cubic-epithelium and vascular-like tubules lined by flattened epithelial
cells or mucin containing signet-ring like cells in between the prostatic
glands were seen. There was no cellular atipia and mitosis. As P63, High-
Molecular-Weight-Cytokeratin(34bE12) and AMACR(alpha-
methylacyl-CoA-racemase) were positive in the lesion, it was diagnosed
as NA.
Conclusion:
NA; which can be seen anywhere with urothelial-lining, is
accepted as a reactive-lesion caused by a previous damage (trauma,TUR,
surgery for lithiasis, renal-transplantation, etc.). As it is a benign condi-
tion, no treatment is needed after the excision for the diagnosis. It is rarely
seen in prostatic-urethra; however should be considered in differential-
diagnosis of suspicious-papillary lesions of the urothelium.
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S352