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was performed, showing a tumour with the same morphology as earlier
lesion.
Conclusion:
Tumours of this type are often associated with an aggressive
clinical course although the majority of PEComas exhibit benign or in-
dolent behavior. To the best of our knowledge, this is the first reported
case of malignant PEComa in such young patient.
E-PS-17-001
Tumours of the thymus: Review of cases in Cruces Universitary
Hospital over the last 5 years
M. Saiz Camín*, L. Mosteiro González, V. Velasco Benito, S.
Malaxetxebarria Unibaso, V. Caamaño Villaverde, M. González
Vadillo, E. Fernández-Lomana Idiondo, M. Atienza Robles, A.
Nogueira Gregorio, A. Marcos Muñoz, G. García de Casasola Rodriguez
*Cruces University Hospital, Dept. of Pathology, Barakaldo, Spain
Objective:
The aim of this study is to classify the cases of thymic epithe-
lial neoplasms, on the basis of the histological classification accepted
(Masaoka stage and WHO types)
Method:
Retrospective study of the medical records and archival tissue
sections of all cases with a diagnosis of thymoma in Cruces University
Hospital between 2012 and 2017
Results:
We found 18 cases, with a mean age of 55.9 years (range 38
–
64).
A slight female predominance was noted (11 cases, 61.1 %). On average,
type B2 was the most frequent tumour, accounting for 27.7 % of
thymomas (5 cases). It is important to notice that we described 3
mixed/combined neoplasms, which consisted of type B3 and B2 compo-
nents. Despite the fact that nearly all the specimens were encapsulated, 8
cases (44.4 %) showed invasion of the adjacent mediastinal fat (stage II)
Conclusion:
Thymoma is a rare malignancy overall, but it is the most
common mediastinal tumour in adults. No environmental, viral or nutri-
tional factors appear to play an etiological role in these neoplasms. They
are more common in middle-aged adults, and mostly found in stage I
(noninvasive). All histological types have the capability to invade, re-
curred and metastasize. Increased survival is closely associated with com-
pleteness of excision.
E-PS-18-001
Morphological and immunohistochemical features of cystic renal tu-
mours in adults
G. Georgescu*, A. Dema, D. Anderco, M. Iacob, D. Herman, M. Botoca,
A. Cumpanas, S. Latcu
*Emergency County Hospital PIUS BRINZEU Timisoara, Romania
Objective:
Predominantly cystic renal neoplasm have been the
source of diagnostic confusion and controversy. Recently epide-
miological data suggest an increasing incidence of these tumours.
The aim of this study was to evaluate the pathological and im-
munohistochemical features of cystic renal tumours.
Method:
A retrospective study was performed in order to identify
patients with cystic renal tumours in a period of 10 years. We
analyzed the clinicopathological characteristics and immunohisto-
chemical profile of these tumours.
Results:
We identified 11 cases of cystic renal tumours: 4 cystic
nephromas(CN), 5 multilocular cystic renal cell carcinoma(MCRCC),1
cystic renal cell carcinoma and 1 cystic synovial sarcoma. CN involved
the left kidney of 4 women with mean age 56 years. 5 patients have
unilateral MCRCC with left predominance, 3 were male and 2 female.
Sixty-six percent of MCRCC were confined to the kidney (pT1); half of
them were associated with other renal lesions including renomedullary
interstitial cell tumour and angiomyolipoma.
Conclusion:
The recognition of MCRCC and CN is very important be-
cause patients may benefit from conservative surgery (nephron-sparing
sugery). The clinical and radiological features may be helpful in charac-
terization of the cystic lesions of the kidney, but only pathological exam-
ination can establish the definite diagnosis.
E-PS-18-002
Anastomosing hemangioma of the kidney: Diagnostic pitfalls and
review of the literature
J. Lobo*, M. Caldas, A. S. Pires-Luís, Â. Rodrigues, R. Henrique
*IPO Porto, Dept. of Pathology, Portugal
Objective:
Vascular lesions of the genito-urinary(GU) tract are overall
infrequent. Anastomosing hemangioma(AH) is a poorly recognized neo-
plasm with strong proclivity for GU organs and may simulate
angiosarcomas. We aim to present a case of AH of the kidney, followed
by a review of all cases reported in literature.
Method:
A 63-year-old male was referred to our Institution with a
4 months history of hematuria and dysuria. Computed tomography(CT)
showed a mass in the right kidney pelvis suggestive of urothelial
neoplasm.
Results:
Nephrectomy specimen showed a 5x3.5 cm well-demarcated
nodule in the upper renal pelvis, with a spongy, mahogany-reddish ap-
pearance. The lesion was composed of anastomosing sinusoidal capillary-
sized vessels arranged in a lobular architecture, with scattered hobnail
endothelial cells exhibiting minimal cytological atypia, along with
non-endothelial supporting-cells. Focal aspects included areas of
moderate/high cytological atypia, vascular thrombi and extra-
medullary hematopoiesis. Immunohistochemistry revealed positiv-
ity for vascular markers and a proliferative index(Ki67) <1 %.
Medline search revealed 117 cases of AH overall, 61(52.1 %)
occurring in GU organs (56 in kidneys, 1 in bladder, 4 in testis/
paratestis).
Conclusion:
AH is a rare entity and it may raise the concern for
angiosarcoma. Pathologists should be aware of this hemangioma variant
in order to avoid overdiagnosis of angiossarcoma.
E-PS-18-003
Postpubertal teratoma with somatic-type malignancy in the form of
Primitive Neuroectodermal Tumour (PNET): A case study with focus
on diagnostic pitfalls and the relevance of reporting this tumour
subtype
J. Lobo*, S. Carvalho, C. Meireles, Â. Rodrigues, R. Henrique
*IPO Porto, Dept. of Pathology, Portugal
Objective:
Somatic-type malignancy(SM) within testicular germ
cell tumours(TGCTs) is a rare event. It occurs more commonly
in metastatic sites after chemotherapy (conveying poor prognosis),
but may also present in the testis, mainly in the context of
postpubertal teratomas(TE). We aim to present a case of a TE
with SM in the form of PNET, focusing on diagnostic pitfalls
and literature review.
Method:
A 52-year-old male presented with diffuse enlargement of the
left testis. Positron emission tomography(PET) favored a malignant tes-
ticular neoplasm with mesenteric lymphadenopathies.
Results:
Morphology and immunohistochemistry on testicular bi-
opsy suggested a small-cell neuroendocrine carcinoma. The orchi-
ectomy specimen, weighing 576 g and measuring 13x11x8.5 cm,
E-PS-17 Thymic and Mediastinal Pathology
E-PS-18 Uropathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S346