ECP 2017 - Abstract Book

Conclusion:

In conclusion, umbilical metastasis is an uncommon

manifestation of visceral malignancies, related to an advanced

disease. Therefore, careful evaluation, including an early biopsy,

of all umbilical lesions is recommended and immunohistochemis-

try is of great value for determining their primary origin.

PS-21-034

Primary pleural primitive neuro-ectodermal tumour: A rare entity

E. Kazdaghli Lagha

, R. Ayadi, A. Blel, M. Ksentini, N. Zneidi, S.

Rammeh

Hopital Charles Nicole, Pathology, Tunis, Tunisia

Objective:

Primary neuro-ectodermal tumours (PNETs) are rare and

highly malignant. Pleural involvement is exceptional. The aim of this

study is to describe its clinico-pathologic features.

Method:

We reported an exceptional case of a pleural PNET.

Results:

A 51-year-old man presented with chest pain, cough and dys-

pnea. Chest computed tomography revealed a pleural compressive mass

with necrosis areas. CT guided biopsy of the mass was performed.

Histological examination revealed an undifferentiated round cells tumour.

The tumour cells were positive for CD99, NSE, pancytokeratin,

synaptophysin and vimentin. Based on these histologic and immunohis-

tochemical findings, the diagnosis of pleural PNET was made. The ex-

tension assessment was negative and the patient was recieved chemother-

apy. Radical pleuro-pneumonectomy, enlarged with pericardium and di-

aphragm with mediastinal lymph node dissection was performed. The

histological examination of the surgical specimen showed the presence

of the same tumour infiltrating the pericardium, the diaphragm and the

pulmonary parenchyma. Operative follow-up was favorable.

Conclusion:

Pleural PNET are exceptional, highly malignant and

very aggressive. They should be considered in the differential

diagnosis of thoracic tumours regardless of the age of the patient.

PS-22-002

High preponderance of BRAF V600E mutation in papillary thyroid

carcinoma (PTC) among Filipinos: A clinicopathologic study

G. A. Espiritu

, D. Ang

Makati Medical Center, Pathology, Philippines

Objective:

BRAF mutation in papillary thyroid carcinomas (PTC)

is associated with an aggressive phenotype, with an incidence of

45 %. We evaluated the prevalence of BRAF mutations in PTC in

Filipino patients, and correlated with clinicopathologic

characteristics.

Method:

From June 2016 to December 2016, clinic-pathologic

data were retrieved from 64 patients who underwent total thyroid-

ectomy. Tumour DNA was isolated using the QIAmp FFPE ex-

traction kit. BRAF exon 15 was amplified using the following

primers: F-TGCTTGCTCTGATAGGA, R-GGCCAAAAATTTAA

TCAGTGG and sequenced with the ABI3500 Genetic Analyzer.

Results:

18/64 (28 %) were diagnosed as PTC. 12 out 17 (70.6 %) PTC

cases harbored BRAF V600E mutation, 1 case failed to amplify.

Demographics of patients with PTC included 13 females, 5 males, medi-

an age of 46 years old (range 25

–

74). 14 cases showed conventional

subtype, 2 follicular variant, 1 oncocytic variant, and 1 with tall cell

features. The average tumour size was 3.01 cm (range 0.8

–

7 cm),

extrathyroidal extension was 7/18 (38.9 %), multifocality 6/18

(33.3 %), and lymph node involvement 8/18 (44.4 %). All parameters

did not predict BRAF mutation.

Conclusion:

Given its associated prognostic value, the high preponder-

ance of BRAF mutation (70.6 %) suggest some correlation with previously

reported lower 5 year survival among Filipinos. This warrants further in-

vestigation in a larger cohort.

PS-22-004

Prevalence and factors associated with vitamin D deficiency among

Afghan adolescents

S. Azizi

French Medical Institute for Children, Dept. of Pathology, Kabul,

Republic of Afghanistan

Objective:

this study aimed to determine the prevalence and identify factors

associated with vitaminD deficiency and severe vitaminD deficiency among

Afghan adolescents (10

–

18 years) diagnosed at French Medical Institute for

Mothers and Children

Method:

An analytical cross-sectional study design was conducted from

Jun to Sep 2016. Blood samples were obtained, serum 25OHD levels were

measured, and the patients were divided into five diagnostic categories

according to their serum 25OHD concentrations. Sufficiency

≥

–

100 ng/ml; Insufficiency 20

–

30 ng/ml; Deficiency < 20 ng/ml; Severe

deficiency < 10 ng/ml; Intoxication >150 ng/ml. Collection of samples

were made at Clinical Laboratory of FMIC and serum 25OHD analyses

were carried out in the Biochemistry section

Results:

A total of 308 adolescents were part of the sample for the final

analysis. Of all, 202(65.6 %) were females and 106(34.5 %) were males.

Out of total, 238(77.3 %) had either insufficiency, deficiency or severe defi-

ciency of vitaminD. Among those, a large number of the participantss

107(34.7 %) had severe vitaminD deficiency, 81(26.3 %) had vitaminD

deficiency, 50(16.2 %) had vitaminD insufficiency, and only 70(22.7 %)

had vitaminD sufficiency. There were two cases of vitaminD intoxication,

who were excluded from the study. Gender, sun-exposure, usage of sun

protector, calcium+ vitaminD supplement intake, VitaminD rich foods intake,

regular milk intake, the type of living in yards or apartments, skin colour of

participants, and BMI were found as significant factors associated with

vitaminD levels

Conclusion:

Low serum vitaminD concentration is prevalent among gen-

eral Afghan population. Screening and ongoing investigation for

vitaminD deficiency should be considered for all adolescents in the coun-

try

PS-22-008

Odontogenic cyst: An epidemiologic study with histopathological

review

A. C. Faur

, C. Balabuc, C. V. Gurban, F. Baderca, C. Zamfir, D. Stef

UMF V. Babes Timisoara, Dept. Anatomy and Embryology, Romania

Objective:

Odontogenic cyst represent a diverse group of pathologic

lesions of the jaws. The current classification of the odontogenic cyst

has two main categories of cyst: developmental and inflammatory. In this

study were reviewed in retrospect all the cystic lesion of the jaws diag-

nosed at City Hospital Of Timisoara over a period of 5 years.

Method:

All the jaw specimens that had a clinical diagnosis of cystic mass

that were received during our study period were included. The clinicopath-

ological data were retreived from the records. The slides were reevaluated,

classified and disscussed.

Results:

We found 185 inflammatory and developmental jaw cysts. The

most common lesions were inflammatory with cases of perapical cysts

(

= 161) and residual cysts (

= 7) followed by developmental

cyst with cases of dentigerous cysts (

= 14) and odontogenic

keratocysts (

= 3). There was a male predominance (

= 97,

Wednesday, 6 September 2017, 09:30

–

10:30, Hall 3

PS-22 Pathology in Favour of Developing Countries

Virchows Arch

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2017

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