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PS-02-040
Hyalinising trabecular tumour: A rare tumour of the thyroid gland
S. Chaieb
*
, S. Hmissa, N. Abdessayed, A. Baccouche, N. Mhamdi, M.
Guerfala, S. Chouchane, A. Bdioui, S. Mestiri, M. Mokni
*
Farhat Hached Hospital, Pathology, Sousse, Tunisia
Objective:
Discuss the histological criteria of hyalinizing trabecular tu-
mour (HTT) and emphasize diagnostic difficulties.
Method:
A 48 years old female patient, with a medical history of breast
cancer, presented with a lump in the left side of the neck.
Results:
Ultrasonography revealed an heterogeneous left isthmolobar
nodule. Isthmectomy was performed. Gross investigation showed an en-
capsulated mass of 3 × 2 × 1 cm. The cut surface was homogeneously
pale and rigid. Microscopically, the nodule was encapsulated. No capsular
or vascular invasions were observed. The tumour was characterized by
trabecular structures separated by fibrous stroma with many calcifica-
tions. The intra-trabecular hyalin was prominent with PAS positivity
and Congo Red negativity. Alveolar structures were also present,
partitioned by sinus vascular network. The tumour cells were oval with
an acidophilic or clear cytoplasm. The nuclei were round with frequent
pseudoinclusions. Immunohistochemical study showed positivity for thy-
roglobulin and negativity for calcitonin, synaptophysin, chromogranin A,
galectin 3 and hormone receptors. MIB-1 staining showed a distinctive
membranous pattern. The diagnosis of HTT was made after eliminating
metastasis of breast cancer, papillary and medullary thyroid carcinomas.
Conclusion:
HTT represents a rare and controversial thyroid tumour
easily confused with papillary or medullary thyroid carcinoma.
Awareness of this entity will allow a better classification and manage-
ment.
PS-02-041
Adrenal myelolipoma: A case report
D. Canoglu
*
, H. F. Baytekin, C. Akarsu, D. Gungor
*
Bakirkoy Training and Research Hospital, Pathology, Istanbul, Turkey
Objective:
Adrenal myelolipoma (AM) is a rare benign tumour that
mostly solitary, asymptomatic, unilateral and non-secreting.
Histologically, it is composed of hematopoietic precursor cells and mature
adipose tissue. The increased use of screening systems, such as ultraso-
nography, computed tomography and magnetic resonance imaging
(MRI), the incidental detection is increasing in frequency.
Method:
We report a case of adrenal giant mass that detected incidentally
in 44-year-old female with no symptoms. There was no finding in phys-
ical examination. Abdominal MRI scan revealed a well-demarcated,
round shaped lesion which was 10 × 8 cm sized and located in left adrenal
region with heterogenous attenuation suggesting the possibility of
myelolipoma. The patient was subjected to left adrenalectomy.
Results:
In gross examination, the specimen was round-shaped, encap-
sulated mass with smooth external surface measuring 10,1 × 8 × 5,7 cm.
Cut surface revealed a solid tumour with a heterogenous appearance of
dark brown and yellowish areas. In histopathologic examination, the tu-
mour composed of bland-looking hematopoietic precursor cells and ma-
ture adipose tissue.
Conclusion:
Although AM is considered to be a rare tumour, widespread
use of imaging modalities and sensitivity of this equipments resulted in
relatively increase of this entity.Therefore pathologists should consider
this tumour in differential diagnosis of adrenal tumours.
PS-02-043
Mary I of England and her tumour: A brief historical and clinico-
pathological review
C. Marques Pontinha
*
, D. Tomás, B. Resende, J. Tavares, E. Alves, D.
Pais, J. O
’
Neill
*
Central Lisboa Hospital Center, Dept. of Anatomic Pathology, Lisbon,
Portugal
Objective:
To discuss the disease that was behind the death of Queen
Mary I of England and Ireland (1516
–
1558).
Method:
Historical records, mainly dated from the 17th century, and
books were reviewed to identify signs and symptoms associated with
Mary
’
s disease. After that a clinicopathological correlation was done
trying to establish her underlying cause of death. Moreover, a brief his-
topathological review about possible diseases was done.
Results:
Mary Tudor was the eldest child of King Henry VIII of England.
Since her childhood, Mary suffered from emotional disorders. Queen
Mary believed herself to be pregnant for twice, but no child ever born.
During Mary
’
s I life her main symptoms were: amenorrhoea, depression,
headaches, palpitation, indigestion, blurry vision, swelling of the abdo-
men and milk secretion. So possible diseases are: an ovarian tumour, an
hydatiform mole or a prolactinoma. Combining all these symptons we
favour a prolactinoma as the tumour behind her death.
Conclusion:
Mary Tudor was ill sinceMay 1558. In suffering, possibly from
an advanced prolactinoma, she died on 17 November 1558. Probably her
direct cause of death was a pituitary apoplexy, a clinical entity first coined in
1950 by Brougham, 45 years later of the first case reported by Bleibtreu.
PS-03-001
A review on new pattern based endocervical adenocarcinoma classi-
fication: Our experience
B. Uguralp
*
, H. F. Baytekin, N. Sever, Y. Ozkan
*
Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
Objective:
Endocervical adenocarcinomas are currently staged according
to the depth of invasion(DOI). Lately a new patern based classification
system was proposed as assesing DOI can be quite challenging and dif-
ficult from case to case. We reevaluated our cases to this new classifica-
tion to investigate the efficacy.
Method:
Case selection was made using our institute
’
s database. Patients
who have undergone radical surgery with lymph node resection were
chosen. Only the usual type endocervical adenocarcinoma was included.
6 cases were involved in this study. Cases were reevaluated according to
the 3 tiered system and correlated with DOI, lymph node metastasis and
lymphovascular invasion.
Results:
Of the 6 cases 3 were classified as Pattern A, 1 was Pattern B and
2 of the cases were Pattern C. None of the patients with Patterns A or B
had lymph node metastasis and lymphovascular invasion. On the contrary
Pattern C patiens had lymphovascular invasion and 1 of them had lymph
node metastasis. There was no association between DOI and patterns.
Conclusion:
Currently endocervical adenocarcinoma management is
based on DOI and it is the single most important decisive factor in lymph
node resection. Since it is a highly discomforting procedure for patients this
new patern based staging may be a better alternative on this call. Additional
large case series and worldwide use of this system must be encouraged.
PS-03-002
Diffuse large B cell lymphoma with plasmablastic differentiation of
the cervix uteri: A case report and review of the literature
M. Yanovytska
*
, L. Zakhartseva, M. Dyatel, I. Zakhartsev
*
Kiev City Oncology Center, Dept. of Pathology, Ukraine
Objective:
Differentiation between diffuse large B cell lymphomas
(DLBCL) with plasmablastic differentiation and true plasmablastic
Sunday, 3 September 2017, 09:30
–
10:30, Hall 3
PS-03 Gynaecological Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S77