113 / 366
PS-04-002
Actinomycosis as an aetiologic agent of refractory tonsillitis: A case
report and review of literature
O. Ajetunmobi
*
, D. Dzuachii, T. Otene
*
Federal Medical Centre, Dept. of Histopathology, Makurdi-Benue State,
Nigeria
Objective:
To describe a case of refractory tonsillitis in an
adult, sequel to granulomatous inflammation induced by
Actinomycetes. To perform a review of relevant literature on the
relationship between Actinomycosis, refractory tonsillitis and
tonsillomegaly.
Method:
Preparation of 3
–
4 micron thick sections tonsillectomy biopsy
obtained from a 51 years old female with refractory tonsillitis. Histologic
analysis of morphologic features in sections stained with Hematoxylin
and Eosin.
Results:
On histology, a fibro-inflammatory process character-
ized by effacement of lymphoid tissue and neighbouring sali-
vary gland acini is observed. Focal areas of necrosis and a
patchy mixed inflammatory infiltrate are observed. Multiple
clusters of radially arranged filamentous basophilic organisms
were seen within the tonsils. A marked necro-inflammatory
reaction is observed adjacent to these clusters. A diagnosis of
Actinomycosis was made, prompting definitive treatment with
antibiotics.
Conclusion:
Refractory tonsillar hyperplasia in adults, in contrast
to children is indicative of relatively sinister aetiologies.
Actinomycosis is a documented cause of tonsillomegaly in adults.
It is a rare disease, and misdiagnosis is common. Microscopy is
the gold standard for definitive diagnosis and as such histologic
examination is essential for all tonsillectomy specimens.
PS-04-003
Case report and review literature of parasite testicular mass mimic to
tumour
A. Artemyeva
*
, A. Chochlova, E. Turckevich
*
Petrov Research Institute, Pathology, St. Petersburg, Russia
Objective:
Parasite infestation of the testis by parasite is rarely
reported and may present with few clinical signs, depending upon
the stage. It may mimic a testicular tumour and we have to
differentiate it. We present a case of a 51-year-old man who
presented with testicular swelling and discomfort for 6 months.
Method:
Clinical examination, ultrasound and imaging suggested an
intrascrotal cystic lesion with a normal testis. However, the intraoperative
findings revealed a tumour-like mass; hence, a orchidectomy was
performed.
Results:
Histopathology reported a diagnosis of a cystic testicular
tunica and spermatic cord with parasite infection by filaria. Cyst
was found, 6 mm in diameter, the wall of which was formed by a
fibrous tissue with thin-walled capillaries. There are infiltration of
histiocytes, eosinophils, lymphocytes with single giant multinucle-
ated cells of foreign bodies. In the cyst cavity, the body of a
filaria was found.
Conclusion:
Here, we review the literature of scrotal and testicular
parasite disease and discuss the course of the appropriate diagnos-
tic management and differential diagnosis involved.
PS-04-004
Pathogens associated with female genital tract infections in Kabul
S. Azizi
*
*
French Medical Institute for Children, Dept. of Pathology, Kabul,
Republic of Afghanistan
Objective:
To determine the vaginal pathogens associated with Genital
Tract Infections
Method:
A cross sectional study design, over a 24-month period
between July 2012 to June 2014, at the Department of
Microbiology, Clinical Laboratory of French Medical Institute
for Mothers and Children, microbiological analyses on samples
were carried out vaginal and high vaginal swab samples were
obtained from women of reproductive age with suspected genital
tract infections and percentage frequencies of isolates were deter-
mined comparatively. Samples were screened for the presence of
vaginal pathogens using conventional microbiological techniques.
Chocolate agar was used for the isolation of fastidious organisms,
Chromagar Candida was employed to isolate and enumerate
Candida species, Bromocresol Purple agar was used for isolation
of members of Enterobacteriaceae while Blood agar base in 10 %
CO2-enriched atmosphere was employed for the isolation of
Gardnerella vaginalis. Microscopic examinations of smears were
carried out to determine the presence of pus cells, yeast cells or
‘
clue cells
’
Results:
Out of 1297 samples, 550 (42.4 %) yielded the growth of
a pathogen. Gardnerella vaginalis recorded the highest prevalence
of 184 (33.45 %), followed by Candida species 135 (24.55 %),
members of Enterobacteriaceae altogether 130 (23.64 %), Gram-
positive cocci 92 (16.73 %) while Neisseria gonorrhea recorded
the least prevalence of 03 (0.55 %). Among the Candida isolates
obtained, Candida albicans was more frequently isolated as com-
pared to non-albicans Candida
Conclusion:
Vaginal pathogens are directly associated with genital tract
infections and this is on the highly prevalent among women in the devel-
oping countries like Afghanistan. There is a dire need for routine evalu-
ation and appropriate intervention in antenatal clinics
PS-04-005
Infectious diseases - my best lung transplant case
K. Wassilew
*
, M. Perch
*
Rigshospitalet, Dept. of Pathology, Copenhagen, Denmark
Objective:
Infection of the pulmonary allograft after lung transplantation
is known to have a negative impact on outcome. Pathological diagnosis
can be challenging, as differential diagnosis includes antibody-mediated
or cellular rejection, which share similar histopathological features.
Method:
We report a case of a 60-year old patient who underwent double
lung transplantation for sarcoidosis. Postoperative period was uncompli-
cated. The patients represented with symptoms of infection 6 month after
lung transplantation.
Results:
Transbronchial biopsies of the pulmonary allograft were nega-
tive for acute cellular rejection and there were no morphological features
of antibody-mediated rejection but organizing pneumonia pattern.
Bacterioscopic stains were negative for microorganisms. Focal squamous
cell metaplasia was present in intrapulmonary airways. Corresponding
autolytic BAL-material contained besides respiratory cells many multi-
nucleate macrophages and showed neutrophil granulocytosis.
Immunohistochemistry was negative for Herpes simplex types 1 &2 but
few budding yeast, compatible with Candida spp were present.
Conclusion:
BAL represents an important diagnostic tool and comple-
ments transbronchial biopsies in the diagnostic setting of infectious dis-
eases in pulmonary allografts.
Sunday, 3 September 2017, 09:30
–
10:30, Hall 3
PS-04 Infectious Diseases Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S99