305 / 366
Objective:
Leiomyoma is a rare tumour of the prostate that is diagnosed
only by the histopathological and immunohistochemical examination.
The differantial diagnoses of leiomyoma from other spindle cell lesions
on prostate is difficult.
Method:
We report a case of low grade smooth muscle tumour in a 66-
year-old man who presented with obstructive urinary symptoms. The case
was initially diagnosed as STUMP at a other center. Its H&E slides and
parafine blocks was brought to our department for a consultation.
Results:
Histopathological analyses showed the tumour composed of the
proliferation of spindle cells, with moderately nuclear atypia and pleo-
morphism. Epithelial tissue was demonstrated at very limited area.
Necrosis is absent. 0
–
1 mitosis was detected in 10 HPF.
Immunohistochemistry demonstrated expression of SMA, desmin,
caldesmon, MSA, pankeratin but no expression of CD34, CD117, bcl-
2. Ki67 proliferation index was 15 %.
Conclusion:
A leiomyoma of the prostate is a rare benign tumour of the
prostate. Most cases are diagnosed at histopathological examination of
prostate biopsies that have been done for benign prostatic hyperplasia.
Differential diagnosis should consist of benign prostatic hyperplasia,
STUMP, solitary fibrous tumour, stromal sarcoma, leiomyosarcoma and
gastrointestinal stromal tumour.
PS-25-134
Prostatic melanosis: A case report
G. Teoman
*
, I. Saygin, S. Mungan, A. S. Teoman, M. E. Ercin
*
Karadeniz Technical University, Pathology, Trabzon, Turkey
Objective:
Prostatic melanosis is a rare lesion that is characterized by
melanocytic proliferation in prostatic stroma and the epithelium. This
lesion is certainly benign and not a precursor of malignant melanoma
but the pathogenesis of the lesion is uncertain. In this paper, a case of
melanosis of the prostate and prostatic adenocarcinoma together in a 67-
year-old man is described and differential diagnosis of the melanocytic
lesions is discussed.
Method:
The surgical specimens were formalin-fixed and paraffin em-
bedded. The section were stained with routinary H&E.
Immunohistochemistry was performed.
Results:
A 67-year-old patient having 1 year history of prostatism symp-
toms. Laboratory test results were normal, except high Prostate Specific
Antigen (PSA) level. Transrectal prostate needle biopsy reported that it
was a prostate cancer with 3 + 4 = 7 Gleason score. After the evaluation,
the patient went for a retropubic radical prostatectomy. Histopathological
and immunhistochemical results were compatible with prostatic
melanosis and prostatic adenocarcinoma.
Conclusion:
Prostatic melanosis is a very rare lesion, only 20 reports
of melanosis have been reported in the literature.Malignant melano-
ma should be kept in mind in differential diagnosis. However the
clinical significance of prostatic melanosis is not clear, urologists
and pathologists should be aware of its existence.
PS-25-135
Prognostic relevance of CA19-9 immunohistochemical expression in
transitional cell carcinoma of the urinary bladder
I. Msakni
*
, F. Gargouri, M. Mhiri, A. Hajji, N. Mansouri, C. Kammoun,
A. Bouziani, B. Laabidi
*
Hôpital Militaire de Tunis, ANAPATH, Tunisia
Objective:
The prognosis of bladder tumours (BT) is still, in some cases,
unpredictable despite the determination of grade and stage. Recent studies
have highlighted the relevance of CA19-9 in determining the
evolutiveness of BT. The aim of our work was to study the immunohis-
tochemical expression of CA19-9 in BT and its correlation with tumour
grade, tumour stage and evolution (recurrence and metastasis.
Method:
We carried out a retrospective study of 74 cases of BT diag-
nosed following endoscopic resection and radical cystoporostatectomy
between 2011 and 2013. Immunoexpression of CA19-9 in tumours was
considered positive in the presence of intense or intermediate immunore-
activity with diffuse distribution. Correlation between CA19-9
immunoexpression and tumour grade, tumour stage and evolution (recur-
rence and metastasis) was assessed.
Results:
Our results showed that the immunohistochemical expres-
sion of CA19-9 was inversely proportional to grade and tumour
stage. The majority of low-grade tumours (
n
= 27/32, 89 %) and
the majority of superficial tumours (
n
= 35/50, 70 %) were pos-
itive for CA19-9. The correlation was statistically significant
(
p
= 0,005 and 0,04 respectively). Recurrence and metastasis were
studied in 56 patients. The immunohistochemical expression of
CA19-9 was proportional to tumour recurrence. The majority of
recurrent tumours (
n
= 16/18, 89 %) were positive for CA19-9.
The correlation was statistically significant (
p
= 0,03). The immu-
noreactivity for CA19-9 showed no correlation with metastasis.
Conclusion:
The CA19-9 seems to allow a better grading and could be
useful for tumour staging. Moreover, this marker would be useful to better
adjust the rhythm of the endoscopic control.
E-Posters
Sunday, 3 September 2017
–
Wednesday, 6 September 2017, 09:00
–
17:15,
Hall 3
E-PS-01-001
Post mortem examination of Dicephalus Parapagus Dibrachius
Dipedis conjoined twins
M. Nweke
*
, O. Iyapo, A. Akinola, O. Adesina, G. Ogun
*
University College Hospital, Pathology, Ibadan, Nigeria
Objective:
Conjoined twins are embryologic abnormalities which
occur due to incomplete division of monozygotic twins. They are
classified based on the most prominent site of union. Our objec-
tive was to use a post-mortem examination for classification and a
detailed description of various co-existing pathologies present
within the conjoined twins
Method:
A 28-year-old gravida 3 Para 2 + 0 presented at the antenatal
clinic of our hospital at a gestational age of 35 weeks. Her ultrasound
report showed a conjoined twin pregnancy. There was a positive family
history of twinning.
Results:
An autopsy was performed following an early demise.
The detailed morphological examination findings include a single
atrium and single ventricle in Twin A, two ventricles in Twin B,
dual pulmonary arteries and hypoplastic lungs in both twins and a
single aorta arising from Twin B. Other anatomical findings are
reported.
Conclusion:
This report illustrates the occurrence of this variant of
conjoined twins with a detailed description of an uncommon car-
diovascular morphology/pathology not routinely encountered in
these type of twins
E-PS-01-002
Incidental post-mortem finding of a vein of galen aneurysm following
a road traffic accident mortality
M. Nweke
*
, F. Onakpoma, G. Ogun, O. Adeleye
*
University College Hospital, Pathology, Ibadan, Nigeria
E-PS-01 Autopsy Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S291