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E-PS-01-012
Sudden death due to a cerebellopontine angle epidermoid cyst
I. Saguem
*
, S. Ben Jomaa, M. Njima, M. Bel Hadj, E. Chouat, Y. Sghaier,
A. Zakhama, A. Chadly, A. Moussa
*
Fattouma Bourguiba Hospital, Dept. of Pathology, Monastir, Tunisia
Objective:
Epidermoid cysts (EC) of the brain are uncommon tumour-
like lesions, most often of congenital origin. We Report a rare case of
sudden death due to large intracranial cerebellopontine angle EC.
Method:
The autopsy and histological findings in an adult male with
sudden unexpected death resulting from an EC of the brain are described
with a review of the related literature.
Results:
A smoker 58-year-old man, presented a month before his death,
with behavioral disorders with notion of repeated fugue. He was found
dead in the public street. The external examination of the body revealed
the presence of a bilateral convergent strabismus and absence of traumatic
lesions. The autopsy showed cerebral edema and a cystic mass of the
cerebellopontine angle compressing the brainstem. Histologic examina-
tion of this mass concluded to an EC. Death would therefore be the
consequence of tonsillar herniation due to a rapid increase of the intracra-
nial pressure.
Conclusion:
Intracranial EC are uncommon brain tumours that account
for 0.2 to 1.8 % of all intracranial tumours. Approximately half of these
cysts are located at the cerebellopontine angle. They are usually symp-
tomatic and therefore easy to diagnose. However, in rare cases they can
lead to death if they are unrecognized.
E-PS-01-013
Metastatic lung cancer: A misleading presentation
C. B. Marta
*
, B. Fuertes, H. Iliev, P. Sota, E. Mejia, G. Muñoz, M. J.
Gimeno, C. Perez
*
HCU Lozano Blesa, Anatomia Patologica, Zaragoza, Spain
Objective:
We present 49 y/o women without history of interest that
came to our emergency room with a pontine haemorrhage. During ad-
mission procedure patient
’
s condition kept declining. Imaging tests re-
vealed multiple brain lesions, reported as cavernomas and a mass in the
right lung. A fine needle puncture aspiration of the lung lesion was per-
formed and diagnosed of non-small-cell lung carcinoma. After 5 days in
hospital the patient died
Method:
The post-mortem examination revealed a 5,5 cm diameter tu-
mour in the right lung hilium, composed of large cells in a glandular
arrangement with lymphovascular invasion. The immunohistochemistry
study was positive for CK7, Ber-Ep4 and MOC 31. According to histol-
ogy and immunophenotype a diagnosis of lung adenocarcinoma was
established. Brain lesions showed clusters of neoplasic cells intermingled
with fibrin, representing tumour emboli.
Results:
The fundamental process was a lung adenocarcinoma which
produced multiple hemorrhagic metastases in the brain, brainstem and
cerebellum. The immediate cause of death was a hemorrhagic pontine
metastasis. Moreover, we demonstrated bilateral bronchopneumonia,
hemorrhagic infarctions and lung edema.
Conclusion:
This is an example of a misleading presentation of a lung
cancer, which lead to the misdiagnosis of the patient and a fatal outcome.
E-PS-02-002
Androgen receptor expression in triple-negative breast cancer
I. Glavynskyi
*
, M. Dyatel, L. Zakhartseva, O. Guz, I. Zakhartsev
*
Kiev City Oncology Center, Dept. of Pathology, Ukraine
Objective:
Triple-negative breast cancer (TNBC) has a poor prog-
nosis because of frequent recurrence. Androgen receptor (AR) is
involved in the pathogenesis of breast cancer, but its role is not
clearly defined. In spite of this, the interest of researchers in
using the androgen receptor as a prognostic and potential thera-
peutic target in TNBC is constantly growing.
Method:
43 cases of triple-negative breast cancer were randomly selected
to determine the presence of androgen receptors using an immunohisto-
chemical method. The age of the patients was 32 to 61 years, the study
was performed on tumours of patients who had not previously received
chemotherapy, hormone therapy or radiotherapy.
Results:
8 patients (18,6 %) of the 43 studied cases was revealed prom-
inent expression of androgen receptors in tumour cells. A decision was
made to prescribe an additional line of antitumour therapy TNBC -
antiandrogen therapy.
Conclusion:
AR expression may be useful as a marker for inclusion in
treatment androgen synthesis inhibitor or synthetic non-steroidal
antiandrogen in TNBC patients. The subsequent study of the role of AR
and its relationship with clinicopathologic features in TNBC will be con-
ducted.
E-PS-02-003
Malignant melanoma in the breast: A case report
E. Gün
*
, D. Etit, S. Yigit, A. Yazici, B. B. Kucukzeybek, A. Er
*
Izmir Katip Celebi University, Pathology, Turkey
Objective:
Malignant melanoma mostly occurs in the skin, mucous
membranes and choroid. Melanoma in the breast is a rarely seen entity.
Method:
An 84-year-old female presented to our General Surgery de-
partment with a complaint of lump in her left breast and axilla. Ultrasound
revealed a dense, cystic lesion (BIRADS IV) in the retroareolar area and a
radiopathological lymph node in the left axilla. She underwent modified
radical mastectomy.
Results:
The gross examination revealed a 6.5 cm tumour located under
the areola expanding into the lower quadrant. Microscopically, the tu-
mour cells were round/oval with large nuclei and nucleoli and abundant
cytoplasm. Immunohistochemical profile of the tumour was compatible
with malignant melanoma. There was no tumoural invasion on the breast
skin. Invasion was detected in 2 of the 11 resected lymph nodes. No
cutaneous or mucosal lesions of malignant melanoma were detected clin-
ically and radiologically after the surgery.
Conclusion:
Malignant melanoma in the breast may simulate other
malignancies; the case we report here raises the awareness of
malignant melanoma and points out that it should always be kept
in mind in rare locations as well as the breast.
E-PS-02-004
Bilateral metachronous breast malignancies: Phyllodes tumour and
NST carcinoma. Case report and literature review
O. C. Voinea
*
, I. Popa, E. Popa, W. Luminita, L. Gabriela, G. Halcu, F.
Vasilescu, G. L. Eftimie, M. Sajin
*
SUUB, Pathology, Bucharest, Romania
Objective:
To describe the clinicopathologic features in a case of a
Phyllodes tumour, a rare type of stromal tumour of the breast and a
metachronous breast carcinoma.
Method:
We present the case of a 68 years old patient with a palpable
nodule in her left breast. After clinic and imagistic investigations that
shown a BIRADS score of 3
–
4, a sectorectomy was performed.
Histopathologic examination reveald a Phyllodes tumour, borderline.
The breast tissue from the periphery of the tumour presented some areas
of florid intraductal hyperplasia and an intraductal papiloma. Two years
later, the patient came back because of another nodule in her right breast,
E-PS-02 Breast Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S294