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Objective:
Dermatofibrosarcoma protuberans (DFSP) is a superfi-
cial infrequent tumour characterized by high rates of local recur-
rence and low risk of metastasis. DFSP occurs most commonly on
the trunk and proximal extremities and it is extremely rare in the
vulva with only a few cases reported.
Method:
We present the case of a 82 year old woman with vulvar mass
involving the left labium mayor and measuring 8 cm. Six months after
surgery the lesion recurred and re-excision was performed.
Results:
Microscopically typical features of DFSP were observed
both arquitectural(non circumscribed, highly cellular, tight
storiform pattern that infiltrates deeply into subcutaneous tissue)
and cytologic (monomorphic spindle cells with scant eosinophilic
cytoplasm and hyperchromatic nuclei)
Conclusion:
DFSP of the vulva is a rare fibrous tumour of low grade
malignancy, with a tendency for local recurrence (rates of 20 to 49 % have
been reported). However, it rarely metastasizes. Management should be
multidisciplinary. Survival rates range from 91 to 100 %. Therefore close
follow-up is recommended.
E-PS-05-019
Desmoplastic melanoma: A pitfall for clinicians and pathologists
S. Pappa
*
, G. Panselinas, B. M. Michaelides, E. Lakiotaki, A.
Kostopoulou, A. Karonidis, D. Tsoutsos, T. Choreftaki
*
G.N.A.
“
G. GENNIMATAS
”
, Surgical Pathology, Athens, Greece
Objective:
Desmoplastic melanoma is a relatively uncommon variant of
spindle-cell melanoma, accounting for less than 4 % of primary cutaneous
melanomas. It can arise de novo (90 %) or in association with other
melanoma subtypes, most often with lentigo maligna. We report a case
of a 74-year-old man who observed change in size in a skin nodule at his
back within last 6 months, clinically diagnosed as basal cell carcinoma.
Method:
We received a grayish skin nodule measuring 1 cm.
Results:
Microscopically a superficial spreading melanoma (SSM) aris-
ing in association with a dysplastic nevus, was diagnosed. Breslows
’
thickness was 2,5 mm without neural involvement. Colliding with the
epithelioid dermal component of SSM we observed spindle cells haphaz-
ardly within a collagenous stroma showing neurotropism, invading
deeper in the reticular dermis. Immunohistochemically, the cells stained
positive for S100 and negative for HMB45, Mart1, SMA, PGM1, CD34,
FXIIIa, CKAE1/AE3. A diagnosis of desmoplastic melanoma in associ-
ation with a SMM was made. Breslows
’
thickness was 4,3 mm
Conclusion:
Desmoplastic melanoma can be a diagnostic challenge
for clinicians and pathologists alike, because of its non-specific
and often banal appearance. Multiple pitfalls exist in achieving
the correct diagnosis and evaluation of all melanoma parameters,
including the initial clinical diagnosis and interpretation errors
under the microscope.
E-PS-05-021
Concomitant sebaceous carcinoma and basocellular carcinoma of the
eyelid : A rare case report with review of the literature
S. Chaieb
*
, S. Mestiri, N. Abdessayed, N. Mhamdi, A. Baccouche, S.
Chouchane, M. Guerfala, A. Bdioui, B. Sriha, M. Mokni
*
Farhat Hached Hospital, Pathology, Sousse, Tunisia
Objective:
We present a rare case of concomitant sebaceous carcinoma
(SC) and basal cell carcinoma (BCC) in the eyelid and discuss the path-
ological and ophthalmic features of these tumours.
Method:
A 78-year-old man presented with an ulcerated nodular lesion
with irregular borders of the right eyelid.
Results:
The patient underwent a biopsy followed by a total excision of
the lesion. On histological examination, the majority of the tumour was
made of a solid pattern of small, round uniform cells with basophilic
cytoplasm, partially intermingled with vacuolated cells indicative of se-
baceous differentiation with many images of perineural invasion. The
cells were immunohistochemically positive for EMA. They were nega-
tive for P40, ACE, pS100, HMB45 and Melan A. The periphery of the
lesion showed a BCC with the typical nest of basal cells with peripheral
palisading. The surgical margins were involved. Based on these findings,
the patient was diagnosed with SC and BCC of the eyelid. The case was
managed as SC. Close follow-up for possible recurrence or appearance of
new lesions was recommended.
Conclusion:
SC and BCC can coexist in the eyelid within the same
clinical lesion. Because of the potential risk of metastasis of SC, close
follow-up of the patients is advisable.
E-PS-06-001
Comparison of the effect of clomiphene citrate and gonadotropins
used for ovulation induction on endometrium: Ultrastructural study
M. Baghirzade
*
, G. Take Kaplanoglu, C. Ilgaz, E. Goktas, D. Erdogan, C.
Elmas
*
Azerbaijan Medical University, Dept. of Pathology, Baku, Azerbaijan
Objective:
Infertility is the inability of the couples to become
pregnant in spite of unprotected regular sexual intercourse during
a year. Our study aims to examine the histological alterations
which could be formed in the uterus tissue as a result of ovula-
tion induction with clomiphene citrate and gonadotropins compar-
atively at the level of fine structure.
Method:
In this experimental study, 36 female 20 weeks old Wistar
rats were used. Rats were randomly divided into 6 groups (control,
hormone and clomiphene citrate induced, also pregnant group for
each drugs) and ovulation induction models have been applied.
(
n
= 6 in each group).
Results:
Mild swelling at surface epithelium cells, mitochondrial
crystolysis, lipid accumulation was observed at ultrastructural lev-
el of hormone induced pregnant group. Basal lamina was thick-
ened. Apical surface specializations were seen to have disap-
peared in the epithelial cells while the gland structure was quite
mature.
Conclusion:
In our opinion hormone application affected implan-
tation more in comparing with the clomiphene citrate application
but it destroyed the structure at the level of surface and glandular
epithelium, and perhaps affected the healthy pregnancy process.
On the other hand clomiphene citrate application did not lead to
damage throughout tissue.
E-PS-07-001
Case report: Awoman with unusual presentation of sporadic medul-
lary thyroid carcinoma
O. Stanowska
*
, E. Bakula, E. Musial, M. Prochorec-Sobieszek
*
Centrum Onkologii- Instytut, Zaklad Patologii i Diagnostyki, Warsaw,
Poland
Objective:
Sporadic medullary thyroid carcinoma appears as distant me-
tastasis in 15 % of the cases at the time of diagnosis. The most common
E-PS-06 Electron Microscopy
E-PS-07 Endocrine Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S314