340 / 366
classic-IL-6 signaling) and HyperIL-6 (via trans-IL-6 signaling) different-
ly activated STAT3. The IL-6R is expressed in CCC patients and influ-
ences overall survival.
Conclusion:
The results demonstrate that, targeting the IL-6/IL-6R/JAK/
STAT pathway members play a crucial role in CCC which might open
doors for novel therapeutic approaches.
E-PS-09-019
Primary pancreaticobiliary location of an uncommon neoplasm: A
report of two cases
S. Chouchane
*
, S. Mestiri, A. Bdioui, N. Mhamdi, N. Abdessaied, M.
Guerfala, A. Baccouche, S. Chaieb, B. Sriha, M. Mokni
*
Farhat Hached Hospital, Pathology, Sousse, Tunisia
Objective:
Carcinosarcoma of the pancreaticobiliary tract is a rare
entity comprising a small subset of all pancreaticobiliary neo-
plasms. This communication aims to highlight its histopathologi-
cal and clinical features.
Method:
We report two cases of carcinosarcoma primary located
in the pancreaticobiliary tract.
Results:
Both patients were 80 years old. They presented with abdominal
pain and jaundice. Computed tomography scan showed abdominal
masses. One patient had a cholecystectomy with a right hemicolectomy,
the other had an extended pancreaticoduodenectomy. Histologicaly,the
first patient was diagnosed with a carcinosarcoma of the gallbladder in-
vading the right colon, the second had a carcinosarcoma of the pancreas.
Conclusion:
Carcinosarcoma of the pancreaticobiliary tract is a
rare entity comprising a small subset of all pancreaticobiliary
neoplasms and very few clinical data and treatment options have
been published.The tumour has cells recognizable as adenocarci-
noma as well as a high-grade spindle-cell component. Each of
these elements shows distinct immunohistochemical and ultra-
structural characteristics.
E-PS-09-020
A rare case of synchronous small cell pancreatic and lung carcinoma,
TTF-1 positive
S. Mavropoulou
*
, Z. Tatsiou, A. Dourou, D. Kasarakis, E. Chamalidou
*
Xanthi General Hospital, Dept. of Pathology, Greece
Objective:
Thyroid transcription factor-1 (TTF-1) plays a crucial
role in morphogenesis of the lungs and and for this reason is
expressed in up to 90 % of pulmonary neuroendocrine cell
carcinomas.
Method:
There have been reports in medical bibliography of
extrapulmopnary small cell carcinomas expressing TTF-1,
approximatelly in 21
–
84 % of cases. This is why in such cases, a great
diagnostic dilemma emerges weather a pulmonary tumour refers to a
primary carcinoma or a metastatic one.
Results:
We report the case of a 78-years-old man in whom a pancreatic
mass was found. During endoscopy of the upper GI track biopsies were
taken through duodenum and histological examination revealed a neo-
plasm with features of a small cell carcinoma, positive in TTF-1 and
neuroendocrine markers. CT-scan revealed metastatic foci in
peripancreatic lymph nodes, peritoneal cavity, adrenal glands and lung
masses. Bronchoscopy was performed and biopsies revealed a neoplasm
with features same as those described above.
Conclusion:
TTF-1 expression in neuroendocrine tumours of the small-
cell type are not uncommon at extrapulmonary locations. The case de-
scribed, as others in bibliography, is suggestive of primary
extrapulmonary carcinoma that express TTF-1. All these neoplasms in
case of synchronous neoplasm with the same histology in lung are
thought to be metastatic, not primary.
E-PS-10-002
Analysis of pap tests in Tepecik Education and Research Hospital as
a quality control measure: An observational study
Ö. Kaya
*
*
Tepecik Education and Research Hospital, Dept. of Pathology, Izmir,
Turkey
Objective:
The pap test is an efficient way of screening cervical
abnormailties. It also can be used as a quality assurence factor.
Objective of this study is to analyze pap smears according to patients
’
age, Ascus / SIL ratio, sufficiency of samples and diagnoses.
Method:
In this study, 1010 smears which reported by 9 patholo-
gists in september 2016, retrospectively analysed by IBM SPSS
statistics 22.
Results:
1010 Pap tests were examined. Among them, there were 29
ASCUS, 2 LSIL, 90 atrophia. 444 of them had enfection. 17 samples
were insufficient. Ascus/ SIL ratio were 14,5. After this diagnosies, 5 of
the patients underwent control smear , 2 patients underwent hysterectomy
and their results were benign. 3 patients underwent cervical biopsy and 2
of them rediagnosed as CIN1.
Conclusion:
Ascus/SIL ratio generally has been used as a quality
control measure. According to previous studies this ratio could
vary from 0.6 to 4.5. In my study this ratio was 14.5. So this
findings were not parallel to the literature. The short duration of
the study, high ratio of infection may affect the results. As a
result, additional precautions should be taken by my instution
for better quality.
E-PS-10-003
Female adnexal tumour of probable Wolffian origin (FATWO): A
case report
S. Carvalho
*
, J. Lobo, C. Meireles, J. Loureiro
*
Portuguese Oncology Institute, Porto, Portugal
Objective:
Female adnexal tumours of probable Wolffian origin
(FATWO) are rare epithelial tumours,first described by
Kariminejad and Scully in 1973. FATWOs are currently regarded
as potentially malignant lesions as 10 % of cases follow an ag-
gressive course,usually when adverse prognostic features are pres-
ent. Herein we present a case of FATWO.
Method:
Description of clinicopathological and prognostic factors of a
case of FATWO.
Results:
36-year-old woman,underwent laparotomy due to a right
adnexal mass shown in ultrasonography. Intraoperatively, a
50 mm mass of the right broad ligament with adhesions to the
right adnexa was found and resected, with capsular rupture.
Macroscopic examination revealed a 49 g white encapsulated sol-
id mass. Histologically, the lesion was composed of epithelioid
and spindle cells arranged in sieve-like, trabecular and solid pat-
terns. Immunoprofile: cytokeratines+,vimentin+, calretinin+
,CD10+, MelanA+,inhibin+, EMA-,CD117-. Five months after di-
agnosis, hysterectomy was performed and residual tumour was
found at uterine serosa. Additional treatments were not performed.
At present, 24 months after diagnosis, the patient is alive without
evidence of disease.
Conclusion:
FATWO are rare tumours that can present a wide diversity
of histological patterns. Surgery is the main treatment as the role of other
therapies remains ill-defined. Long-term surveillance is advised since
recurrences and/or metastasis can occur, especially when adverse prog-
nostic factors are identified.
E-PS-10 Gynaecological Pathology
Virchows Arch
(
2017
)
471
(
Suppl 1
):
S1
–
S352
S326