ECP 2017 - Abstract Book

“

International Myeloma Working Group

”

were enrolled in this study. Age,

gender, and the distribution pattern and positivity of CD20 and cyclin

D1expression on multiple myeloma cells in bone marrow were evaluated.

Results:

Twenty-one percent of cases express CD20 and 14 % express

cyclin D1 which is in agreement with the results of the literature. The

expression of CD20 was associated with a particular

“

lymphocytoid

”

morphology and the expression of cyclin D1 was associated with massive

medullary infiltration.

Conclusion:

CD20 and Cyclin D1 may have a prognostic influence in

patients with multiple myeloma

E-PS-11-007

Diffuse large B-cell lymphoma occurring in a patient with

lymphoplasmacytic Lymphoma/Waldenstrom macrogloblinemia

Y. Kato*, S. Ota, Y. Hino, C. Ohwada, E. Sakaida, Y. Takeda, C.

Nakaseko, Y. Nakatani

*Chiba University, School of Medicine, Japan

Objective:

Lymphoplasmacytic lymphoma/Waldenstrom

macrogloblinemia (LPL/WM) is a low-grade lymphoma. Diffuse large

B-cell lymphoma (DLBCL) reportedly occurs in approximately 13 % of

LPL/WM cases.

Method:

A 51-year-old man was followed for cold agglutinin disease and

mild anemia. The patient had general malaise and dyspnea on exertion for

2 months, and was worse in the past month.

Results:

CT scan and FDG-PET revealed hepatosplenomegaly and mul-

tiple lymphadenopathy including cervical lymph nodes. Lymph node

SUVmax by FDG-PET was 6.2. The initial clinical diagnosis of WM/

LPL was based on the elevated IgM level and symptoms of hyperviscos-

ity syndrome. Immediate plasma exchange therapy improved the clinical

symptoms and IgM levels. The clinical course was more rapid than that of

the typical LPL. Pathological diagnosis of DLBCL with plasma cell dif-

ferentiation was based on large lymphoid cell proliferation in lymph node

specimen and additional immunohistochemistry analysis.

Conclusion:

Both of clinical and pathological diagnosis suggested

“

DLBCL occurring in a patient with LPL/WM

”

. Histological transforma-

tion in patients with LPL/WM is rare, but the frequency is the highest for

DLBCL. However, there are case reports of transformation to HL or PBL.

Transformation of LPL/WM has a prognosis similar to that of DLBCL

and a 40 % chance of surviving 5 years.

E-PS-11-008

Mantle cell lymphoma cervico-facial location

N. Mhamdi*, S. Mestiri, N. Abdessayed, S. Chouchane, S. Chaieb, M.

Guerfala, A. Bacouch, A. Benabdelkader, M. Mokni

*Farhat Hached Hospital, Pathology Dept., Sousse, Tunisia

Objective:

Mantle cell lymphoma (ML) is a rare non-Hodgkin lympho-

ma that accounts for 2

–

10 % of lymphomas. It affects adults of middle or

advanced age, with male predilection. Clinically, it is often manifested as

a disseminated disease with splenomegaly, medullary invasion and par-

ticular tropism for the digestive mucous. A revealing facial or cervical

localisation is rarely found. We describe 2 new Tunisian cases.

Method:

Two male patients aged 64 and 48 years, consulting for dyspha-

gia and cervical mass. Physical examination reveals an indurated and

painful swelling of the left amygdale in the first patient and magma of

cervical and axillary adenopathies in the second.

Results:

Histopathological examination revealed a diffuse lymphoid pro-

liferation, made of small cells, with irregular nuclei, without visible nu-

cleolus. The immunohistochemical study showed a positivity of CD20,

CD5 and cyclin D1. CD10 and CD23 were negative. The two patients had

chemotherapy,with Rituximab in the 2nd patient. Out comes were favor-

able in both patients, with no evidence of relapse.

Conclusion:

The diagnosis of mantle cell lymphoma is

anatomopathological and immunohistochemical. Cervical involvement

is found most often in advanced stages of the disease, but may be the

presenting sign as in the case of our patients.

E-PS-11-009

Thyroid lesions with marked plasmacytic differentiation: A two case

report

N. Bilalovic*, A. Chikha

*UKC Sarajevo, Klinicka Patologija i Citologi, Bosnia and Herzegovina

Objective:

Introduction/Aim: Head and neck lymphomas have distinc-

tive epidemiologic and clinicopathologic features including an associa-

tion with immunosuppression, infectious organisms or autoimmune dis-

orders. Lymphomas of the thyroid gland constitute up to 5 % of thyroid

neoplasms. Primary thyroid lymphoma is an uncommon thyroid

malignancy.The most common type of lymphoma in the thyroid gland,

followed by MALT lymphoma (10

–

30 %). The treatment modalities sig-

nificantly differ from other thyroid malignancies. Frequently it is accom-

panied by Hashimoto

’

s thyroiditis, and it may be difficult to differentiate

the two entities histologically.

Method:

Case report: We present here two cases of incidental lesions of

thyroid gland showing lymphoplasmacytic infiltration with the formation

of germinal centers, destruction of the normal thyroid follicular architec-

ture, Hürthle cell changes.

Results:

The lymphoplasmacytic infiltration in both cases were positive

for CD79

, and negative for CD20 and PAX5, there was no aberrant

expression of CD56, cyclin D1, CD5, CD10, and CD43

Conclusion:

Conclusion: Plasma cell differentiation is found in approx-

imately one third of MALT lymphomas and is often accompanied with

the production of monoclonal immunoglobulin with prominent plasma

cell differentiation that can mimic plasmacytoma.The differential diagno-

sis between a plasmocytoma and a MALT lymphoma with marked plas-

ma cell differentiation may be tricky, as they may have a similar histo-

logical appearance and both may arise in chronic thyroiditis backgrounds.

E-PS-12-001

Prevalence of Human papillomavirus (HPV) associated oropharyn-

geal squamous cell carcinoma (OPSCC) in Hungary

A. Slezák*, E. Tóth

*National Institute of Oncology, Dept. of Surgical and Molecular

Pathology, Budapest, Hungary

Objective:

Increasing prevalence of human papillomavirus (HPV) in

oropharyngeal squamous cell carcinoma (OPSCC) has been reported in

Europe. In OPSCC, expression of tumour suppressor p16 is used as a

surrogate marker of HPV infection and has prognostic value. We aimed to

investigate the epidemiology of OPSCC in our institute.

Method:

141 surgically removed or biopsy specimens were analyzed

from the oropharyngeal region. Immunohistochemical (IHC) reaction

for p16 was carried out in 141 cases of formalin fixed paraffin embedded

material to identify HPV-positive OPSCC. Results were evaluated semi

quantitatively.

Results:

Patients were aged between 38 and 88 year (mean 62 year), the

male to female ratio was 106 and 35 respectively. Tumour specimens

from 43 of 141 (30,5 %) patients were classified as p16-positive and 98

(69,5 %) were p16-negative based on IHC analysis for p16 by qualified

pathologists. Both p16-positive and negative tumours were

E-PS-12 Head and Neck Pathology

Virchows Arch

(

2017

)

471

(

Suppl 1

–

S352

S332